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目的探讨血浆8-异前列腺素F2а(8-iso-prostaglandin F2α,8-isoPGF2α)水平与早期糖尿病肾病的关系及临床意义。方法选择2型糖尿病患者63例,分为单纯糖尿病组(22例)和早期糖尿病肾病组(41例);以同期健康查体者31例作为正常对照组,用ELISA法检测3组血浆8-isoPGF2а水平,并进行统计学分析。结果单纯糖尿病组、早期糖尿病肾病组和对照组患者血浆8-isoPGF2а水平分别为(394.5±104.1)pg/ml、(562.7±211.8)pg/ml和(292.7±66.7)pg/ml,组间比较差异有统计学意义(F=13.907,P<0.001)。与对照组比较,单纯糖尿病组及早期糖尿病肾病组8-isoPGF2а水平显著升高,差异有统计学意义(P<0.05,P<0.001);与单纯糖尿病组比较,早期糖尿病肾病组8-isoPGF2а水平明显升高,差异有统计学意义(P=0.001)。血浆8-isoPGF2а水平与HbA1c呈显著正相关(r=0.349,P=0.012)。结论2型糖尿病肾病早期氧化应激水平明显增加,检测血浆8-isoPGF2а水平对于预测早期糖尿病肾病可能具有一定临床意义。
Objective To investigate the relationship between plasma 8-iso-prostaglandin F2α (8-iso-prostaglandin F2α, 8-isoPGF2α) and early diabetic nephropathy and its clinical significance. Methods Sixty-three patients with type 2 diabetes mellitus (T2DM) were divided into simple diabetic group (n = 22) and early diabetic nephropathy group (n = 41). Thirty-one healthy controls were enrolled in this study. Plasma 8- isoPGF2а levels, and statistical analysis. Results The plasma levels of 8-isoPGF2a in patients with simple diabetes, early diabetic nephropathy and control group were (394.5 ± 104.1) pg / ml, (562.7 ± 211.8) pg / ml and (292.7 ± 66.7) pg / ml, respectively The difference was statistically significant (F = 13.907, P <0.001). Compared with the control group, the level of 8-isoPGF2a in diabetic patients and diabetic nephropathy group was significantly increased (P <0.05, P <0.001). Compared with diabetic patients, the level of 8-isoPGF2а in diabetic patients with early diabetic nephropathy Was significantly higher, the difference was statistically significant (P = 0.001). Plasma 8-isoPGF2а levels were positively correlated with HbA1c (r = 0.349, P = 0.012). Conclusion The early stage of oxidative stress in patients with type 2 diabetic nephropathy obviously increases. The detection of plasma 8-isoPGF2а level may be of clinical significance in predicting early diabetic nephropathy.