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目的探讨我院住院抗菌药物使用频度与细菌耐药性之间的关系。方法统计我院2006年～2008年住院抗菌药物的用药频度和细菌室分离细菌监测的药敏结果,并对用药频度和细菌耐药的相关性进行分析。结果2006年～2008年我院住院7类抗菌药物的用药频度(DDDs)平均年增幅为47.5%,11种常用抗菌药物总体也呈上升,种院内感染的主要病原菌对11种常用抗菌药物中有64.5%的4耐药率高于40%,抗菌药物的DDDs与细菌耐药性呈正相关。结论医院应该多方面促进抗菌药物的合理使用,减缓细菌耐药性的发生。
Objective To investigate the relationship between the frequency of hospital use of antibacterials and bacterial resistance in our hospital. Methods The frequency of antibacterials in hospital from 2006 to 2008 and the drug susceptibility results of bacteriological monitoring of bacteria isolated in our hospital from 2006 to 2008 were analyzed. The correlation between frequency of drug use and bacterial resistance was analyzed. Results The average frequency of DDDs in hospital from 2006 to 2008 was 47.5%, and 11 kinds of commonly used antimicrobial agents also showed a general increase. Among the 11 kinds of commonly used antimicrobial agents There are 64.5% 4 resistance rate higher than 40%, DDDs antibacterial drugs and bacterial resistance was positively correlated. Conclusion The hospital should promote the rational use of antibacterials in many aspects and slow down the occurrence of bacterial resistance.