AIM:To evaluate the role and our experience of injecti-on sclerotherapy with cow milk in the treatment of rectal prolapse in children.METHODS:In the last 30 years (1976-2006) we made 100 injections of sclerotherapy with cow milk in 86 chil-dren.In this study we included children who failed to respond to conservative treatment and we perform ope-rative treatment.RESULTS:In our study we included 86 children and in all of the patients we perform cow milk injection sclerot-herapy.In 95.3% (82 children) of patients sclerotherapy was successful.In 4 (4.7%) patients we had recurrent rectal prolapse where we performed operative treatment.Below 4 years we had 62 children (72%) and 24 older children (28%).In children who needed operative trea-tment we performed Thiersch operation and without any complications.CONCLUSION:Injection sclerotherapy with cow milk for treatment rectal prolapse in children is a simple and effective treatment for rectal prolapse with minimal com-plications.