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目的探讨早期肠内营养对特发性肺间质纤维化治疗后肠功能障碍的影响。方法特发性肺间质纤维化治疗后肠功能障碍患者120例根据随机数字表法分为治疗组与对照组各60例,对照组给予肠外营养支持治疗,治疗组给予肠内营养支持治疗,干预周期为10 d。结果 2组干预前的肺总量(TLC)与肺活量(FVC)值、血清前白蛋白(PA)与白蛋白(ALB)值、CD3+、CD4+、CD8+人类细胞亚群值的差异均无统计学意义,干预后治疗组的TLC与FVC值、血清PA与ALB值、CD3+和CD4+值明显提高,与对照组比较,差异有统计学意义(P<0.05)。两组干预期间的腹胀、腹痛、恶心等并发症发生率比较,差异无统计学意义(P>0.05)。结论早期肠内营养应用于特发性肺间质纤维化治疗后肠功能障碍患者能有效改善患者的肺部与胃肠功能,安全性好,其作用机制的发挥与改善免疫功能有关。
Objective To investigate the effect of early enteral nutrition on intestinal dysfunction after idiopathic pulmonary fibrosis. Methods A total of 120 patients with intestinal dysfunction after idiopathic pulmonary fibrosis were divided into treatment group and control group according to the random number table method, 60 cases in each group. The control group was given parenteral nutrition support, and the treatment group was given enteral nutrition support , The intervention period is 10 d. Results There was no significant difference in the values of total lung volume (FVC), serum albumin (ALB), albumin (ALB), CD3 +, CD4 +, CD8 + human cell subsets before intervention Significance, after treatment, TLC and FVC values, serum PA and ALB values, CD3 + and CD4 + values of the treatment group were significantly increased, compared with the control group, the difference was statistically significant (P <0.05). There was no significant difference in complication rates of abdominal distension, abdominal pain and nausea between the two groups (P> 0.05). Conclusion Early enteral nutrition for patients with intestinal dysfunction after idiopathic pulmonary fibrosis can effectively improve lung function and gastrointestinal function of patients, and its mechanism of action is related to the improvement of immune function.