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目的 :研究肺癌放射导向手术中肿瘤及正常组织P糖蛋白 (P gp)、Ki 67抗原表达与放射性核素摄取比 (T/NT)的关系。方法 :采用免疫组化方法和显微图像分析技术 ,测定 3 2例接受放射导向手术的肺癌病人P gp和Ki 67抗原表达 ,分析P gp和Ki 67的标记指数 (LI)与T/NT之间的相关性。 结果 :P gp和Ki 67的LI和肺癌病人T/NT之间均有相关性 (r =-0 .61,P =0 .0 0 0 2 ;r =0 .75,P =0 .0 0 0 1)。结论 :Ki 67的LI越高 (肿瘤增殖越旺盛 ) ,T/NT值越高 ;P gp阳性的肿瘤 ,T/NT值较低
Objective : To study the relationship between the expression of P glycoprotein (P gp), Ki 67 antigen and radionuclide uptake ratio (T/NT) in tumor and normal tissues during radio-guided lung cancer surgery. METHODS: Immunohistochemistry and microscopic image analysis techniques were used to determine the expression of P gp and Ki 67 antigens in 32 lung cancer patients undergoing radiation-guided surgery. The labeling index (LI) and T/NT of P gp and Ki 67 were analyzed. Inter-relatedness. Results: There was a correlation between P gp and Ki 67 LI and lung cancer patients T/NT (r = -0.61, P = 0.020; r = 0.75, P = .0 0 0 1). Conclusion: The higher the Ki of Ki 67 (the more proliferating the tumor is), the higher the T/NT value; the lower the T/NT value of P gp-positive tumors.