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目的观察乌拉地尔单用或与多巴酚丁胺、多巴胺、呋塞米联合治疗难治性心力衰竭的疗效和安全性。方法 95例难治性心力衰竭患者分为3组,A组31例为对照组,应用洋地黄类药物、利尿剂、硝酸甘油等常规治疗。B组32例为乌拉地尔组,在对照组基础上加用乌拉地尔针。C组32例为联合治疗组,在乌拉地尔组基础上加用多巴酚丁胺、多巴胺、呋塞米。结果联合治疗组总有效率(95%)高于乌拉地组(84%)(P<0.05);乌拉地尔组亦高于对照组(65%)(P<0.05)。结论乌拉地尔治疗难治性心力衰竭疗效显著,与多巴酚丁胺、多巴胺、呋塞米合用效果更好。
Objective To observe the efficacy and safety of urapidil combined with dobutamine, dopamine and furosemide in the treatment of refractory heart failure. Methods Ninety-five patients with refractory heart failure were divided into three groups. Group A (n = 31) served as control group. The patients were treated with digitalis drugs, diuretics and nitroglycerin. B group 32 cases of urapidil group, based on the control group with urapidil needle. C group 32 patients for the combined treatment group, based on the use of urapidil with dobutamine, dopamine, furosemide. Results The total effective rate (95%) in the combined treatment group was significantly higher than that in the urapidil group (84%) (P <0.05), that in the urapidil group was also significantly higher than that in the control group (65%) (P <0.05). Conclusion Urapidil has a significant therapeutic effect on refractory heart failure and is more effective than dobutamine, dopamine and furosemide.