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采用LSAB免疫组化染色方法对41例食管鳞癌中CD1a阳性Langerhans细胞(LC)和CD4、CD8阳性T淋巴细胞进行标记。结果:60.98%(25/41)癌组织中可见CD1a阳性LC,63.41%(26/41)有CD4+淋巴细胞,39.02%(15/41)有CD8+T淋巴细胞浸润,经统计学处理发现CD1a+LC与CD4+T淋巴细胞浸润有相关性,与CD8+T淋巴细胞无明显关系。结论:食管鳞癌组织中CD1a+LC可能与CD4+淋巴细胞的激活有关,但T细胞在肿瘤免疫中可能存在信号传递的异常,不能有效地激活CD8+T淋巴细胞。
LSAB immunohistochemical staining was used to label CD1a-positive Langerhans cells (LC) and CD4 and CD8 positive T lymphocytes in 41 cases of esophageal squamous cell carcinoma. Results: CD1a-positive LC was found in 60.98%(25/41) cancer tissues, CD4+ lymphocytes were found in 63.41%(26/41), and CD8+T lymphocytes infiltrated in 39.02%(15/41). The study found that CD1a+LC was associated with CD4+ T lymphocyte infiltration and had no significant relationship with CD8+ T lymphocytes. Conclusion: CD1a+LC in esophageal squamous cell carcinoma may be related to the activation of CD4+ lymphocytes. However, T cells may have abnormal signal transduction in tumor immunity and can not effectively activate CD8+ T lymphocytes.