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采用ＬＳＡＢ免疫组化染色方法对４１例食管鳞癌中ＣＤ１ａ阳性Ｌａｎｇｅｒｈａｎｓ细胞（ＬＣ）和ＣＤ４、ＣＤ８阳性Ｔ淋巴细胞进行标记。结果：６０．９８％（２５／４１）癌组织中可见ＣＤ１ａ阳性ＬＣ，６３．４１％（２６／４１）有ＣＤ４＋淋巴细胞，３９．０２％（１５／４１）有ＣＤ８＋Ｔ淋巴细胞浸润，经统计学处理发现ＣＤ１ａ＋ＬＣ与ＣＤ４＋Ｔ淋巴细胞浸润有相关性，与ＣＤ８＋Ｔ淋巴细胞无明显关系。结论：食管鳞癌组织中ＣＤ１ａ＋ＬＣ可能与ＣＤ４＋淋巴细胞的激活有关，但Ｔ细胞在肿瘤免疫中可能存在信号传递的异常，不能有效地激活ＣＤ８＋Ｔ淋巴细胞。
LSAB immunohistochemical staining was used to label CD1a-positive Langerhans cells (LC) and CD4 and CD8 positive T lymphocytes in 41 cases of esophageal squamous cell carcinoma. Results: CD1a-positive LC was found in 60.98%(25/41) cancer tissues, CD4+ lymphocytes were found in 63.41%(26/41), and CD8+T lymphocytes infiltrated in 39.02%(15/41). The study found that CD1a+LC was associated with CD4+ T lymphocyte infiltration and had no significant relationship with CD8+ T lymphocytes. Conclusion: CD1a+LC in esophageal squamous cell carcinoma may be related to the activation of CD4+ lymphocytes. However, T cells may have abnormal signal transduction in tumor immunity and can not effectively activate CD8+ T lymphocytes.