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用光化学法诱导大鼠血栓形成性局部脑缺血，观察组氨酸对脑血栓形成后皮层Ｎａ＋，Ｃａ２＋含量、脑水肿及心功能障碍的影响，脑血栓形成后皮层Ｎａ＋，Ｃａ２＋及脑水份明显增加（ｐ＜０．０ｌ），左室收缩压峰值（ＬＶＳＰ）由１９１０±１．４４ｋＰａ降至１７．２±１５．３０ｋＰａ，心室收缩与舒张最大速率（±ｄｐ／ｄｔｍａｘ）分别由８４０．００±１３５．９０ｋＰａ和６３８．９０±１４６、１０ｋＰａ降至６４５．００±ｌ１０．２０ｋＰａ和４７０．３０±１０６．４０ｋＰａ（Ｐ＜０．０５）．ｉＶ组氨酸５ｍｇ·ｋｇ－１可明显改善脑缺血所致脑水肿从心功能障碍，而只有保护作用．给药后２４ｈ动物平均动脉压（ＭＡＰ）及ＬＶＳＰ比照组高（Ｐ＜０．０５），机理有待研究。
To observe the effect of histidine on cerebral cortex Na +, Ca2 + content, cerebral edema and cardiac dysfunction after photothrombosis induced thrombotic cerebral ischemia in rats. To observe the effect of histidine on cortical Na +, Ca2 + and brain water content after cerebral thrombosis LVSP decreased from 1910 ± 1.44kPa to 17.2 ± 15.30kPa, and the maximum systolic and diastolic velocities (± dp / dtmax) were increased from 840 to 840, respectively. 00 ± 135.90 kPa and 638.90 ± 146,10 kPa to 645.00 ± l10.20 kPa and 470.30 ± 106.40 kPa (P <0.05). iV histidine 5mg · kg-1 can significantly improve cerebral edema caused by cerebral ischemia from cardiac dysfunction, and only the protective effect. The average arterial pressure (MAP) and LVSP control group (P <0.05) 24 hours after administration, the mechanism to be studied.