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慢性肝性脑病或门体脑病(PSE)对饮食变化、抗生素治疗以及摄入不消化的双糖如乳果糖有高度反应。本研究旨在评估PSE及其治疗对胃肠转运时间的影响。 对象与方法:30例平均42.5岁男性均为需作肝移植的终末期慢性肝病患者,过去未作胃手术,无糖尿病、无嗜酒,除研究所需外停服任何药物,且嘱吸烟者戎烟24h,受试前6周禁酒。研究组为PSE0(无脑病)或1级患者,0级者经系列神经精神学测试后分为2组:10例无脑功能失调,另10例有可辨识的脑功能失调(亚临床肝性脑病)。此外,对10例有明显1级PSE的患者取坐位作胃排空试验,将γ照相机置其后,在零时吞下含0.5 mCi ~(99m)Tc-硫胶的试餐,随后每隔1分钟作系列扫描60次,扫描资料贮存于电脑内备分析。在受试者摄入
Chronic hepatic encephalopathy or portal encephalopathy (PSE) is highly responsive to dietary changes, antibiotic therapy, and the ingestion of indigestible disaccharides such as lactulose. This study was designed to evaluate the effect of PSE and its treatment on gastrointestinal transit time. PARTICIPANTS AND METHODS: Thirty patients (average 42.5 years old) were all patients with end-stage liver disease undergoing liver transplantation. In the past, no gastric surgery, no diabetes and no alcohol were required. Except for research, Rong smoke 24h, six weeks before the test forbidden alcohol. The study group was PSE0 (no encephalopathy) or grade 1 and grade 0 was divided into two groups after a series of neuropsychiatric tests: 10 without brain dysfunction and the other 10 with identifiable brain dysfunction (subclinical hepatic Encephalopathy). In addition, 10 patients with significant grade 1 PSE were asked to sit in the stomach for a gastric emptying test. After the gamma camera was set, a test meal containing 0.5 mCi- (99m) Tc-Sulfide was swallowed at zero, 1 minute for a series of scanning 60 times, scanning data stored in the computer for analysis. In subjects intake