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目的:研究左乙拉西坦(LEV)单药或添加对学龄期儿童癫痫患儿脑电活动的影响。方法:选取我院确诊为癫痫的学龄期儿童96例,给予LEV单药或添加治疗12个月,观察患儿脑电图间歇期痫性放电(IEA)的改善情况及LEV对脑电背景活动的影响。结果:与治疗前比较,治疗12个月末患儿脑电图IEA改善率为83.72%,脑电图α波频率减慢(t=3.09,P<0.01),θ波频率增快(t=4.64,P<0.01),δ波增快(t=2.64,P<0.05)。结论:LEV可明显抑制学龄期癫痫儿童脑电图IEA,对脑电背景活动有明显改善作用。
Objective: To investigate the effects of levetiracetam (LEV) monotherapy or addition on EEG activity in children with school-age children with epilepsy. Methods: A total of 96 school-aged children diagnosed with epilepsy in our hospital were enrolled in this study. LEV monotherapy or 12-month treatment was given. The improvement of intermittent electroencephalogram (IEA) and the effect of LEV on the background of EEG Impact. Results: Compared with those before treatment, the improvement rate of EEG in children with EEG was 83.72% at the end of 12 months of treatment, the frequency of alpha wave was slowed down (t = 3.09, P <0.01) , P <0.01), the δ wave was faster (t = 2.64, P <0.05). CONCLUSION: LEV can significantly inhibit IEA in children with school-age epilepsy, which has a significant effect on background activity of EEG.