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目前广泛用于临床诊断急性冠脉综合征(acute coronary syncrome,ACS)的心肌损伤标志物,如心肌肌钙蛋白(cTn)和肌酸激酶同工酶(CK-MB)均表现为在心肌坏死后血中浓度升高,而超声心动图核素显像等手段诊断ACS,均需心肌出现一定程度损伤,这些均不利于ACS的早期诊断。最近研究发现,缺血修饰清蛋白(ischemia modified albumin,IMA)是较为理想的心肌缺血标志物,具有极高的灵敏度,能在心肌损伤早期可逆阶段检测出来,已成为当前学术界研究的热点。
Cardiac injury markers such as cardiac troponin (cTn) and creatine kinase isoenzyme (CK-MB) are widely used in the clinical diagnosis of acute coronary syndrome (ACS) After the blood concentration increased, and echocardiographic radionuclide imaging and other means of diagnosis of ACS, a certain degree of myocardial damage required, these are not conducive to the early diagnosis of ACS. Recent studies have found that ischemia modified albumin (IMA) is an ideal marker of myocardial ischemia with high sensitivity and can be detected in the early stage of myocardial injury reversal, which has become a hot research topic in current academic circles .