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目的:热拉伸会改变纤维的结构和性能,进而影响由纤维编织而成的支架的性能。本文考察了PGLA纤维的拉伸倍数对编织支架在SD大鼠皮下的体内降解行为的影响。方法:制备了基于生物可降解高分子材料聚乙交酯丙交酯(PGLA,GA/LA摩尔比=90/10)的完全生物可降解编织支架,通过测试支架在大鼠体内降解过程中的失重、表面形貌、热性能、径向压缩力等变化情况,考察了纤维的不同的拉伸倍数对支架体内降解过程的影响。结果:用拉伸倍数为5的PGLA纤维编织的支架在植入SD大鼠皮下后降解最慢,重量、吸水率、结晶度、化学成分和径向压缩力的变化最慢,植入体内10天后能够保持完整的支架形态。结论:纤维的拉伸倍数会影响由纤维编织成的支架的热性能和力学性能的变化,本研究结果表明这种新的手工编织的支架具有短暂支撑管腔狭窄的潜在应用,为支架的材料选择和制备方法提供了参考,为在体内起到短暂支撑作用的支架的深入研究提供了实验基础。
Purpose: Hot stretching changes the structure and properties of the fiber, which in turn affects the performance of the braid made of fiber. In this paper, the effect of PGLA fiber draw ratio on the in vivo degradation of braided scaffolds in SD rats was investigated. Methods: A completely biodegradable braided scaffold based on polylactide-lactide (PGLA, GA / LA molar ratio = 90/10) was prepared by measuring the scaffold in the degradation process of rats Weight loss, surface topography, thermal properties and radial compressive force. The effects of different stretching ratios of fibers on the degradation process were investigated. Results: The scaffold weaved with PGLA fibers with a stretch factor of 5 exhibited the slowest degradation and the slowest changes in weight, water absorption, crystallinity, chemical composition and radial compressive force after subcutaneous implantation into SD rats. Days to maintain the integrity of the stent form. CONCLUSIONS: The draw ratio of fibers affects the thermal and mechanical properties of the braided fiber braided stent. Our results show that this new hand-braided stent has the potential to provide short-term support for luminal stenosis, as the material for the stent Selection and preparation methods provide a reference for the in-depth study of scaffolds that provide transient support in vivo.