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目的:为某院老年患者铜绿假单胞菌感染比阿培南的合理使用提供依据。方法:收集我院64株铜绿假单胞菌(PA),采用2倍琼脂稀释法测定比阿培南的最低抑菌浓度(MIC),蒙特卡洛模拟计算比阿培南6种给药方案的达标概率(PTA)和累积反应分数(CFR)。结果:比阿培南所有方案对铜绿假单胞菌(PA)的CFR均<90%,对敏感铜绿假单胞菌(S-PA),65~74岁组中300 mg,q6h方案的CFR为93.02%;≥75岁组中600 mg,q12h和300 mg,q8h/q6h方案的CFR分别为95.66%,96.18%和98.52%。结论:不建议某院老年人PA感染时单用比阿培南,对多重耐药铜绿假单胞菌(MDR-PA)应换用其他抗菌药物,对S-PA可选择300 mg,q6h方案。
Objective: To provide basis for rational use of biapenem in Pseudomonas aeruginosa infection in elderly patients in a hospital. Methods: 64 strains of Pseudomonas aeruginosa (PA) were collected in our hospital. The minimum inhibitory concentration (MIC) of biapenem was determined by 2-fold agar dilution method. The six dosage regimens of biapenem were calculated by Monte Carlo simulation The probability of compliance (PTA) and cumulative response score (CFR). Results: All the programs of biapenem had CFR <90% to Pseudomonas aeruginosa (PA), and the CFR of 300 mg and q6h in the sensitive Pseudomonas aeruginosa (S-PA) Was 93.02%. The CFR of 600 mg, q12h and 300 mg, q8h / q6h in the group of ≥75 years old were 95.66%, 96.18% and 98.52% respectively. CONCLUSIONS: It is not advisable to use biapenem alone for PA infection in elderly patients in a hospital and to replace MDR-PA with other antibiotics, and to choose 300mg and q6h regimens for S-PA .