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目的:研究和探讨布地奈德雾化吸入对小儿肺炎治疗机制分析与系统评价。方法:选取2012年11月~2014年11月我院收治的80例小儿肺炎患儿为研究对象,按治疗方法不同分为观察组(40例,布地奈德雾化吸入治疗),对照组(40例,常规治疗),对比两组患者的治疗效果。结果:观察组患儿治疗后血清TNF-a、IFN-y、IL-4含量及不良反应总发生率均显著低于对照组,差异有统计学意义(P<0.05);观察组患儿治疗总有效率(97.5%)显著高于对照组患儿治疗总有效率(80.0%),差异有统计学意义(P<0.05)。结论:采用布地奈德雾化吸入治疗小儿肺炎,可减少促炎因子含量,提高治疗总有效率,降低不良反应发生率,临床可广泛应用。
Objective: To study and explore the therapeutic mechanism and systemic evaluation of budesonide inhalation on children with pneumonia. Methods: Eighty children with pneumonia of pneumonia admitted from November 2012 to November 2014 in our hospital were selected as study objects. According to the different treatment methods, they were divided into observation group (40 cases, budesonide inhalation therapy), control group ( 40 cases, routine treatment), compared the treatment effect of two groups of patients. Results: The levels of serum TNF-a, IFN-γ and IL-4 in the observation group were significantly lower than those in the control group after treatment (P <0.05). The treatment group The total effective rate (97.5%) was significantly higher than the control group, the total effective rate of treatment (80.0%), the difference was statistically significant (P <0.05). Conclusion: The use of budesonide atomized inhalation in children with pneumonia can reduce the content of proinflammatory cytokines, improve the total effective rate and reduce the incidence of adverse reactions, which can be widely used clinically.