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观察了22例中重度高血压患者静注可乐宁后的血液动力学、心电图、血压及心率的改变,发现静注2小时内心肌收缩力明显减弱并有明显的体位性血压改变。其中4例ST-T有动态改变,提示用药后可引起冠脉供血不足,认为对高血压合并严重冠心病或左心衰者应慎用。
The changes of hemodynamics, electrocardiogram, blood pressure and heart rate after intravenous injection of clonidine in 22 patients with moderate-severe hypertension were observed. The contractility of myocardium was obviously weakened within 2 hours after intravenous injection and significant changes of orthostatic blood pressure were observed. Of which 4 cases of ST-T have a dynamic change, suggesting that medication can cause coronary insufficiency, that hypertension should be used with caution in patients with severe coronary heart disease or left heart failure.