用乌拉坦(700mg/kg)和氯醛糖(70mg/kg)麻醉的Wistar系雄性大鼠,观察了药物刺激蓝斑对血压和心率以及肾交感神经活动的影响。结果表明,蓝斑内注射谷氯酸、乙酰胆碱均使血压明显降低、心率显著减慢,蓝斑内注射谷氨酸又能使肾交感神经自发放电活动明显减弱。上述效应具有明显的剂量依赖性。以上结果表明,谷氨酸和乙酰胆碱兴奋蓝斑可产生降压效应,其效应可能与心率减慢和外周交感神经紧张性降低有关。 Wistar male rats anesthetized with urethane (700 mg / kg) and chloralose (70 mg / kg) were tested for their effects on blood pressure and heart rate and renal sympathetic nerve activity. The results showed that intracortical injection of glutamic acid and acetylcholine decreased blood pressure significantly, heart rate significantly slowed, intracortical injection of glutamic acid can make spontaneous renal sympathetic firing activity was significantly weakened. The above effect has obvious dose dependence. The above results show that glutamate and acetylcholine blue spots can produce antihypertensive effect, the effect may be related to slow heart rate and decreased peripheral sympathetic tone.