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文章首次以乙基纤维素为壁材,采用溶剂蒸发法制得艾叶粉水溶液微胶囊。正交实验得出制备微胶囊的最佳工艺条件为:乙基纤维素︰芯材︰乙酸乙酯︰水相=1︰2.5︰13︰130(质量比),搅拌速度:1500 r/min,乳化时间:15 mim,水油两相混合搅拌时间:10 min。通过扫描电镜表征结果显示,所得微胶囊固体颗粒呈球形,分散性好,粒径在20～200μm范围内。实验制得微胶囊最大载药量为48.07%,具有良好的包覆效果。透析缓释实验表明,微胶囊在37.0℃恒温生理盐水浸泡60 h后,仍有艾叶药理活性成分存在,较好地延长了储藏时间和药物有效作用时限。
The article for the first time to ethyl cellulose as the wall material, solvent evaporation method obtained Ai Ye powder aqueous solution microcapsules. Orthogonal experiments showed that the optimum conditions for the preparation of microcapsules were: ethylcellulose: core material: ethyl acetate: aqueous phase = 1︰2.5︰13:130 (mass ratio), stirring speed: 1500 r / min, Emulsion time: 15 mim, water and oil mixing time: 10 min. Characterization by scanning electron microscopy showed that the resulting microcapsules solid spherical particles, good dispersion, particle size in the range of 20 ~ 200μm. The maximum drug loading capacity of the microcapsules was 48.07%, with good coating effect. The results of dialysis sustained release experiments showed that after the soaking of microcapsules in physiological saline at 37.0 ℃ for 60 h, the pharmacological active ingredients still existed in the leaves, which prolonged the storage time and effective time limit of the drug effectively.