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目的探讨柳氮磺胺吡啶联合微生态制剂治疗溃疡性结肠炎的临床效果及价值。方法 59例溃疡性结肠炎患者随机分为微生态制剂组(A组,n=29)和联合用药组(B组,n=30)两组。A组采用微生态制剂疗法,B组采用柳氮磺胺吡啶联合微生态制剂疗法,对比两组患者治疗效果,记录Mayo指数、大便菌群积分情况。结果 1 B组患者治愈23例,总有效率为96.67%,明显优于A组患者,组间对比差异具有统计学意义(P<0.05);2两组患者治疗后Mayo指数及大便菌群积分情况均较治疗前降低,其中B组患者上述2指标分别为(1.7±0.18)和(1.90±0.85)分,明显低于A组患者,组间对比差异具有统计学意义(P<0.05)。结论采用柳氮磺胺吡啶联合微生态制剂方案治疗溃疡性结肠炎疗效确切,可有效降低患者大便菌群水平、抑制黄嘌呤氧化酶及氧自由基生成,消除肠道病灶,安全可靠。
Objective To investigate the clinical effect and value of sulfasalazine combined with probiotics in the treatment of ulcerative colitis. Methods Fifty-nine patients with ulcerative colitis were randomly divided into two groups: probiotics group (group A, n = 29) and combination group (group B, n = 30). Group A was treated with probiotics. Group B was treated with sulfasalazine combined with probiotics. The treatment effect was compared between the two groups. The Mayo index and stool flora score were recorded. Results In group B, 23 patients were cured and the total effective rate was 96.67%, which was significantly better than that of group A (P <0.05) .2 The Mayo index and stool flora score (1.7 ± 0.18) and (1.90 ± 0.85) points respectively in B group, which were significantly lower than those in A group (P <0.05). Conclusion Sulfasalazine combined with probiotics in the treatment of ulcerative colitis is effective and can effectively reduce the level of stool flora, inhibit the formation of xanthine oxidase and oxygen free radicals, eliminate intestinal lesions, and is safe and reliable.