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目的:检测结直肠癌(CRC)组织中富含半胱氨酸的分泌性酸性蛋白质(SPARC)、基质金属蛋白酶-2(MMP-2)和血管内皮生长因子(VEGF)的表达状况,探讨其与CRC临床病理因素、预后的关系。方法:采用通用型二步法测定60例CRC中SPARC、MMP-2和VEGF的表达情况。结果:SPARC在CRC肿瘤细胞的表达低于肿瘤间质的表达,χ2=14.545,P=0.000。SPARC在肿瘤细胞低表达者,无进展生存期(PFS)和总生存期(OS)都短于高表达者,P=0.000。相反,MMP-2高表达者,PFS(P=0.024)和OS(P=0.022)都短于低表达者。VEGF高表达者,PFS短于低表达者,P=0.029,而OS差异无统计学意义,P=0.139。结论:SPARC在肿瘤细胞的低表达促进了CRC的侵袭转移,其可能促进了MMP-2和VEGF的表达,因此检测SPARC、MMP-2和VEGF的表达情况可预测CRC的预后。
Objective: To investigate the expression of cysteine-rich secretory acidic protein (SPARC), matrix metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF) in colorectal cancer And CRC clinicopathological factors, prognosis. Methods: The expression of SPARC, MMP-2 and VEGF in 60 CRC patients were determined by the universal two-step method. Results: The expression of SPARC in CRC tumor cells was lower than that in tumor stroma, χ2 = 14.545, P = 0.000. SPARC in tumor cells with low expression, progression-free survival (PFS) and overall survival (OS) were shorter than those with high expression, P = 0.000. In contrast, patients with high MMP-2 expression had shorter PFS (P = 0.024) and OS (P = 0.022) than those with lower expression. Those with high VEGF expression had shorter PFS than low expression, P = 0.029, but no significant difference in OS (P = 0.139). Conclusion: The low expression of SPARC in tumor cells promotes the invasion and metastasis of CRC, which may promote the expression of MMP-2 and VEGF. Therefore, detecting the expression of SPARC, MMP-2 and VEGF can predict the prognosis of CRC.