硒是人体必需的微量元素,是谷胱甘肽过氧化物酶(Glutathione peroxidases,GPXs)及其他含硒酶的活性中心,在机体内发挥多种生物学功能。适量硒对重金属和非金属毒性具有解毒作用。硒还可通过GPXs和硫氧还蛋白还原酶(Thioredoxin reductases,TrxRs)等含硒酶的抗氧化活力抵抗有毒元素引起的氧化损伤[1]。鉴于硒的上述作用,硒在职业卫生领域中的应用越来越广泛,其功能学研究已成为毒理学研究的热 Selenium is an essential trace element of the human body and is an active center of Glutathione Peroxidases (GPXs) and other selenium-containing enzymes, and plays a variety of biological functions in the body. Appropriate amount of selenium has detoxification effect on heavy metal and non-metal toxicity. Selenium also protects against oxidative damage caused by toxic elements through the antioxidant activities of selenium-containing enzymes such as GPXs and Thioredoxin reductases (TrxRs) [1]. In view of the above effects of selenium, selenium has become more and more widely used in the field of occupational hygiene and its functional study has become a hot topic in toxicological research