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7例急性白血病缓解期患者(男性4例,女性3例;平均年龄29±9a),因真菌感染服用酮康唑0.2g, bid。在服药前及服药后7d分别测定卧位醛固酮、雌二醇和睾酮,以了解该药对甾体类激素的影响。结果表明7例患者服用酮康唑后醛固酮水平均明显降低。临床应用中应注意这一副作用。
Seven patients with acute leukemia in remission (4 males and 3 females; mean age 29 ± 9 years) were treated with ketoconazole 0.2 g bid for fungal infections. 7d before taking medication and determination of abdominal aldosterone, estradiol and testosterone, in order to understand the drug on steroid hormones. The results showed that 7 patients after ketoconazole aldosterone levels were significantly lower. The clinical application should pay attention to this side effect.