糖尿病是由于体内胰岛素绝对或相对不足,从而引起糖、脂肪和蛋白质代谢紊乱的一种常见病和多发病。其病因和发病机理尚不十分清楚,从目前的研究来看,与遗传关系极为密切。为了阐明糖尿病的发病机理,进而对这一严重危害人类健康的疾病提供预防和病因学治疗方法、建立一个理想的、近似人类糖尿病的动物模型是非常必要的。中国地鼠在近亲繁殖过程中,可以自发的产生糖尿病,其病理变化具有人类糖尿病的许多特征,比应用化学药物如四氧嘧啶(alloxan)、链尿霉素(streptozotocin)造成胰 Diabetes is due to the absolute or relative lack of insulin in the body, causing a common disease and frequently-occurring disease of sugar, fat and protein metabolism disorder. The etiology and pathogenesis is not yet clear, from the current study, the genetic relationship is extremely close. In order to elucidate the pathogenesis of diabetes and to provide a preventative and etiological treatment for this disease, which is seriously endangering human health, it is necessary to establish an ideal animal model that is similar to human diabetes. Chinese gophers spontaneously develop diabetes during their inbreeding, and their pathological changes have many characteristics of human diabetes. They are more specific than chemical drugs such as alloxan and streptozotocin