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目的探索艾滋病病毒感染者与人类白细胞抗原(HLA)不同基因型的关系,并评价艾可清胶囊治疗人类免疫缺陷病毒(HIV)感染者的效果。方法收集HIV感染35例,艾滋病(AIDS)患者51例,其中HIV感染者服用艾可清胶囊,AIDS患者服用抗病毒西药,采用聚合酶链式反应-序列特异性引物技术(PCR-SSP)检测所有患者的HLA-B基因型,并进行Karnovsky评分和T淋巴细胞亚群、血常规检测,并对艾可清胶囊疗效的危险因素进行分析。结果 AIDS患者Bw4Bw4基因型的CD4、CD8及Th/Ts治疗后与治疗前相比明显升高,Bw4Bw6基因型的CD4和Th/Ts治疗后与治疗前相比亦明显升高(P<0.01)。HIV感染者不同基因型T细胞治疗前后变化无统计学意义(P>0.05)。艾可清胶囊效佳组治疗后CD4、Karnovsky评分、体重、白细胞、淋巴细胞绝对值均较治疗前明显上升(P<0.05或P<0.01);年龄为影响艾可清胶囊疗效的主要因素。结论携带HLA-Bw4Bw4基因型患者免疫功能恢复快于其他基因型,说明人类自身遗传背景可以影响病情进展,并发现艾可清胶囊可能对40岁以下人群效果更佳。
Objective To explore the relationship between human immunodeficiency virus (HIV) and different genotypes of human leukocyte antigen (HLA) and to evaluate the effect of AIQING capsule in treating human immunodeficiency virus (HIV) infection. Methods 35 cases of HIV infection and 51 cases of AIDS were collected. Among them, HIV-infected patients took Ai-qing capsule and AIDS patients took antiviral western medicine. PCR-SSP was used to detect HIV- HLA-B genotypes of all patients, and Karnovsky score and T lymphocyte subsets, blood tests, and analysis of the risk factors for the efficacy of Ai Keqing capsule. Results The CD4, CD8 and Th / Ts genotypes of Bw4Bw4 genotype in AIDS patients were significantly higher than those before treatment, and the levels of CD4 and Th / Ts in Bw4Bw6 genotype were significantly higher than those before treatment (P <0.01) . There was no significant difference in T cells of different genotypes among HIV-infected patients before and after treatment (P> 0.05). After treatment, the values of CD4, Karnovsky score, body weight, white blood cells and lymphocytes in AIQI Capsule group were significantly higher than those before treatment (P <0.05 or P <0.01). Age was the main factor influencing the efficacy of AIQI Capsule. Conclusion The immune function recovery of patients with HLA-Bw4Bw4 genotype is faster than that of other genotypes, indicating that the genetic background of human beings can affect the progression of the disease and that Aiqin Capsule may be more effective in people under 40 years of age.