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在反相悬浮体系中以K2S2O8-NaHSO3引发N,N-′亚甲基双丙烯酰胺与淀粉的接枝共聚,制备了淀粉接枝共聚物微球。用人工肠液对所得淀粉微球进行体外降解,运用FT-IR、SEM、粒度分析仪对微球及其降解产物进行了表征分析,用正交实验分析了合成因素对微球粒径的影响。结果表明:共聚物微球形态圆整,平均粒径50.2μm,微球中存在酰氨基结构。正交实验表明:N,N-′亚甲基双丙烯酰胺和油水比对微球的平均粒径影响较大;体外降解表明:微球在3～4 h内基本维持稳定聚合结构,之后降解迅速。
In the reversed-phase suspension system, K2S2O8-NaHSO3 was used to initiate the graft copolymerization of N, N’-methylenebisacrylamide and starch to prepare starch graft copolymer microspheres. The obtained starch microspheres were degraded in vitro using artificial intestinal juice. The microspheres and their degradation products were characterized by FT-IR, SEM and particle size analyzer. The effects of synthesis factors on the particle size were analyzed by orthogonal experiments. The results showed that the morphology of the copolymer microspheres was round and the average particle size was 50.2μm. The amido structure existed in the microspheres. Orthogonal experiments show that: N, N ’methylene bisacrylamide and oil-water ratio of the average particle size of microspheres significantly; in vitro degradation showed that: microspheres in the 3 ~ 4 h to maintain a stable polymeric structure, and then degradation rapid.