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目的探讨肥胖儿童伴假性黑棘皮病与胰岛素抵抗及2型糖尿病的关系。方法对42例肥胖伴假性黑棘皮病儿童,60例单纯性肥胖儿童及20例正常儿童的空腹血糖及胰岛素水平、空腹血糖/ 胰岛素比值及人体测量学参数[腰围/臀围比值(wHR)、全身体脂含量、体脂百分数、体质指数]进行分析比较,并对肥胖伴假性黑棘皮病儿童组与单纯性肥胖儿童组行葡萄糖耐量试验,以比较两组患儿的糖耐量异常情况。结果假性黑棘皮病组有2例诊断为2型糖尿病,21例糖耐量异常,明显高于单纯肥胖儿童组;葡萄糖耐量试验提示60 min及120 min的血糖水平显著高于单纯肥胖组(P<0.01)。人体测量学参数包括腰围/臀围比值、全身体脂含量、体脂百分数、体质指数及空腹血胰岛素水平明显高于单纯性肥胖组(P<0.01)和对照组(P<0.01),空腹血糖/胰岛素比值明显低于单纯肥胖组(P<0.0I)和对照组(P<0.01)。结论儿童假性黑棘皮病与肥胖、高胰岛素血症、胰岛素抵抗密切相关,是发生2型糖尿病的高危人群。
Objective To investigate the relationship between macaque pseudarthrosis of Acanthosis nigricans and insulin resistance and type 2 diabetes in obese children. Methods The fasting blood glucose and insulin levels, fasting blood glucose / insulin ratio, and anthropometric parameters [waist circumference / hip ratio (wHR)) in 42 obese patients with acanthosis nigricans, 60 simple obesity children and 20 normal children were measured. , Total body fat content, body fat percentage, body mass index] were analyzed and compared, and glucose tolerance test was conducted in children with obesity with acanthosis nigricans and simple obesity children to compare the impaired glucose tolerance . Results Two cases of type 2 diabetes and 21 cases of impaired glucose tolerance were diagnosed in the group of pseudo acanthosis nigricans, which was significantly higher than that of simple obesity children. Glucose tolerance test showed that the levels of blood glucose in 60 minutes and 120 minutes were significantly higher than those in simple obesity group <0.01). The anthropometric parameters including waist circumference / hip ratio, body fat percentage, body fat percentage, body mass index and fasting blood insulin level were significantly higher than those in simple obesity group (P <0.01) and control group (P <0.01) / Insulin ratio was significantly lower than the simple obesity group (P <0.01) and the control group (P <0.01). Conclusion Children with pseudothecism acanthosis nigricans and obesity, hyperinsulinemia, insulin resistance are closely related to the occurrence of type 2 diabetes at high risk.