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目的:探讨急性脑卒中患者血浆心房钠尿肽(ANP)的变化及其临床意义。方法:对76例脑梗死患者(脑梗死组)和16例脑出血患者(脑出血组)于发病后第1、2、3周采用放射免疫法测定血浆ANP水平,以30例健康体检者(对照组)的血浆ANP水平作为对照。结果:在发病后各时间点,脑梗死组和脑出血组血浆ANP水平均明显高于对照组(P<0.01)。发病后第1周脑出血组血浆ANP水平明显高于脑梗死组(P<0.05),第2、3周仍高于脑梗死组,但差异均无显著性意义。2组发病后第1周与第2周比较差异均无显著性意义。结论:血浆ANP水平的增高在一定程度上反映了脑组织受损的严重程度,也与高血压和机体的应激反应有关。
Objective: To investigate the changes of plasma atrial natriuretic peptide (ANP) in patients with acute stroke and its clinical significance. Methods: Plasma levels of ANP were measured by radioimmunoassay in 76 patients with cerebral infarction (cerebral infarction group) and 16 patients with intracerebral hemorrhage (cerebral hemorrhage group) at week 1, 2 and 3 after onset. Thirty healthy subjects Control) plasma ANP level as a control. Results: At each time point after onset, the levels of ANP in cerebral infarction group and cerebral hemorrhage group were significantly higher than those in control group (P <0.01). The level of plasma ANP in the cerebral hemorrhage group was significantly higher than that in the cerebral infarction group (P <0.05). The levels of ANP in the cerebral hemorrhage group were still higher than those in the cerebral infarction group at the second and third week. However, the difference was not significant. There was no significant difference between the first and the second week after the onset of disease in the two groups. Conclusion: The increase of plasma ANP level reflects the extent of brain damage to a certain extent, and also is related to hypertension and the body’s stress response.