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目的研究住院肺结核患者中,耐多药和广泛耐多药结核病的发生情况,为结核病防控提供依据。方法收集2007—2009年住院肺结核患者资料,对发生耐多药结核病者进行监控,并对部分患者做二线药敏感性测定,对广泛耐多药结核病的发生进行监测管理并探索管理措施。结果 2007—2009年,耐药结核病发生率从31.4%降到20.2%,耐多药结核病从16.2%降至9.4%,均呈下降趋势;对其中66例做2线药物敏感性检测,检出广泛耐多药结核5例(7.6%)。结论住院肺结核患者中,耐多药和广泛耐多药结核病均占较高比例,应及时发现并加以监控管理。
Objective To study the incidence of multidrug-resistant and multidrug-resistant tuberculosis (TB) in hospitalized patients with pulmonary tuberculosis (TB) and provide basis for tuberculosis prevention and control. Methods The data of inpatients with pulmonary tuberculosis from 2007 to 2009 were collected to monitor the occurrence of multidrug-resistant tuberculosis. Second-line drug susceptibility testing was performed on some patients and monitoring and management of a wide range of multi-drug resistant tuberculosis were carried out. Results From 2007 to 2009, the incidence of drug-resistant TB decreased from 31.4% to 20.2%, and MDR-TB dropped from 16.2% to 9.4%, both of which showed a decreasing trend. Sixty-six of these patients were tested for 2-line drug susceptibility. A wide range of multidrug-resistant tuberculosis in 5 cases (7.6%). Conclusions Among the hospitalized patients with tuberculosis, MDR-TB and MDR-TB account for a high proportion and should be promptly discovered and monitored.