异丙酚具有起效快、时效短、体内无蓄积、苏醒迅速而平稳 ,术后恶心呕吐发生率低等优点 ,而广泛用于麻醉诱导和维持[1 ] 。咪唑安定则具有半衰期较短 ,镇静、遗忘作用等特点。自 1996年以来我们以小剂量咪唑安定复合小剂量异丙酚用于口腔肿瘤手术的麻醉 ,取得了满意的效果 ,现 Propofol has the advantages of fast onset, short duration, no accumulation in the body, rapid and stable recovery, low postoperative nausea and vomiting, and is widely used in the induction and maintenance of anesthesia [1]. Midazolam has a shorter half-life, sedation, forgetting effect and so on. Since 1996, we have been using small doses of midazolam combined with low-dose propofol anesthesia for oral cancer surgery, and achieved satisfactory results.