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Population-based incidence data from Europe on the disease burden of lower re spiratory tract infections (LRTI) due to respiratory syncytial viruses (RSV), pa rainfluenza viruses (PIV) and influenzaviruses (IV) are lacking, especially with respect to the disease burden. In a 2-year prospective multicentre study of ch ildren aged < 3 years in Germany, we registered populationbased cases as outpati ents (n = 2386), inpatients (n =2924), and nosocomially-acquired (n = 141). Nas opharyngeal secretions were tested for viral RNA. The annual incidence for physi cian visits per 100 children for all LRTI was 28.7, RSV 7.7, PIV 3.8 and IV 1 .1.Annual hospitalisation rates per 105 children were for all LRTI 2941, RSV 1 117, PIV 261 and IV 123.Annual nosocomial cases per 105 hospital days were for all LRTI 79, RSV 29, PIV 9 and IV 1.5.All five children (0.27%) who died had an underlying disease and fourwere nosocomially acquired. Conclusion: Hospitali sation rates due to lower respiratory tract infections in healthy children were similar to those reported elsewhere; the rates for out-patient visits were appr oximately ten times higher.
Population-based incidence data from Europe on the disease burden of lower re spiratory tract infections (LRTI) due to respiratory syncytial viruses (RSV), pa rainfluenza viruses (PIV) and influenzaviruses (IV) are lacking, especially with respect to the disease burden burden . In a 2-year prospective multicentre study of children aged <3 years in Germany, we registered population based cases as outpatints (n = 2386), inpatients (n = 2924), and nosocomially-acquired (n = 141). Nas ophryngeal secretions were tested for viral RNA. The annual incidence of physi cian visits per 100 children for all LRTI was 28.7, RSV 7.7, PIV 3.8 and IV 1 .1.Nannual hospitalization rates per 105 children were for all LRTI 2941, RSV 1 117 , PIV 261 and IV 123. An nnual nosocomial cases per 105 hospital days were for all LRTI 79, RSV 29, PIV 9 and IV 1.5. All five children (0.27%) who died had an underlying disease and four were nosocomially acquired. Conclusion: Hospitali sation rates due to lower respiratory tract in fections in healthy children were similar to those reported elsewhere; the rates for out-patient visits were appr oximately ten times higher.