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过去认为脑梗死是公认的高发病率、高致残率的老年性疾病。近年来随着中青年脑梗死发病率的逐年提升,关于中青年脑梗死发病机制的研究正成为关注焦点。颈动脉粥样硬化斑块是老年性脑梗死的重要发病基础,也与中青年脑梗死的发病关系密切,其中斑块性质特别是易损斑块起着关键性的作用,机制包括易损斑块所致管腔狭窄、易损斑块的易损性、易损斑块继发的局部血流动力学紊乱。本文就颈动脉易损斑块与中青年脑梗死的概念、颈动脉易损斑块在中青年脑梗死中的发病机制予以综述。
In the past that cerebral infarction is recognized as a high incidence, high morbidity rate of senile diseases. In recent years, with the increasing incidence of young and middle-aged cerebral infarction, the research on the pathogenesis of middle-aged and young cerebral infarction is becoming the focus of attention. Carotid atherosclerosis plaque is an important pathogenesis of senile cerebral infarction, but also with the incidence of cerebral infarction in young and middle-aged closely related to the plaque, especially the vulnerable plaque plays a key role, mechanisms include vulnerable spots Stenosis caused by lumps, vulnerability to vulnerable plaque, and local haemodynamic disorders secondary to vulnerable plaque. In this paper, the concept of carotid vulnerable plaque and middle-aged cerebral infarction, carotid vulnerable plaque in young and middle-aged cerebral infarction pathogenesis are reviewed.