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桥本脑病(又称自身免疫性甲状腺炎相关的糖皮质激素敏感性脑病)是与桥本甲状腺炎相关的以神经系统症状为主要表现的疾病,呈急性或亚急性起病,出现癫痫发作、震颤、肌阵挛、共济失调、精神病等表现,有复发及缓解交替过程。桥本脑病患者有高滴度的抗甲状腺抗体,甲状腺功能正常或异常,脑脊液蛋白质含量升高,脑电图呈弥漫性慢波,大部分影像学检查无异常,少数出现白质T2加权相弥漫性信号增强。目前发病机制还不清楚。现报道一例桥本脑病患者。建议在临床工作中如果遇到无法解释的脑病时,如果抗甲状腺抗体滴度高,即使甲状腺功能正常也要考虑桥本脑病的可能性。
Hashimoto Encephalopathy (also known as autoimmune thyroiditis-related glucocorticoid-sensitive encephalopathy) is a disease associated with Hashimoto’s thyroiditis that manifests as a neurological symptom, with acute or subacute onset, seizures, Tremor, myoclonus, ataxia, psychosis and other performance, recurrence and mitigation of alternating process. Hashimoto’s encephalopathy patients have high titer of anti-thyroid antibodies, normal or abnormal thyroid function, elevated cerebrospinal fluid protein content, EEG diffuse slow wave, most of the imaging examination without exception, a small number of white matter T2-weighted phase diffuse Signal enhancement. The current pathogenesis is unclear. A case of Hashimoto’s encephalopathy is reported now. Proposed in clinical work if you encounter unexplained encephalopathy, if anti-thyroid antibody titer, even if the thyroid function is normal also consider the possibility of Hashimoto’s encephalopathy.