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目的 :观察尿酸氧化酶静脉溶栓治疗急性脑梗死的临床疗效。方法 :将发病时间小于 2 4h的脑梗死患者随机分为治疗组与对照组。治疗组 2 9例 ,男 2 1例 ,女 8例 ,平均年龄 (5 1.2± 10 .1)岁 ,静脉滴注国产尿酸氧化酶 15 0万U。对照组 3 0例 ,男 14例 ,女 16例 ,平均年龄 5 9.84岁 ,每日静脉滴注脉通 5 0 0 m L ,连用 14 d。观察两组 3 h、6h、12h、2 4h、14 d、2 1d及 2 8d神经功能缺损评分及临床疗效。结果 :治疗组 2 8d神经功能缺损评分低于对照组 (P<0 .0 5 ) ,治疗组临床有效率 86%高于对照组 63 % ,且有统计学差异 (P<0 .0 5 )。结论 :尿酸氧化酶静脉溶栓治疗脑梗死安全、有效。
Objective: To observe the clinical effect of intravenous thrombolysis of uric acid oxidase in the treatment of acute cerebral infarction. Methods: The patients with cerebral infarction whose onset time was less than 24 hours were randomly divided into treatment group and control group. There were 29 cases in the treatment group, 21 males and 8 females, with an average age of (5 1.2 ± 10. The control group 30 cases, 14 males and 16 females, mean age 5 9.84 years old, daily intravenous infusion of 500 ml, for 14 d. The neurological deficit score and clinical efficacy at 3h, 6h, 12h, 24h, 14d, 21d and 28d were observed in both groups. Results: The score of neurological deficit in the treatment group at 28 days was lower than that in the control group (P <0.05). The clinical effective rate in the treatment group was 86% higher than that in the control group (63%) (P <0.05) . Conclusion: Uricase oxidase intravenous thrombolytic treatment of cerebral infarction safe and effective.