抗体依赖性细胞介导的细胞毒性作用(ADCC)在肿瘤免疫和同种异体移植物排斥机制中得到重视以后,Butterworth等首先发现类似的ADCC也存在于抗寄生虫的保护性免疫应答中。在曼氏血吸虫病人血清存在下,人末梢血的多核白细胞可将血吸虫童虫杀死,进一步研究表明效应细胞是嗜酸性细胞(Eos)。之后,人们对有关寄生虫的ADCC进行了广泛深入的研究,靶子涉及到多种线虫和原虫,效应细胞也包括了巨噬细胞、中性白细胞和NK细胞等。然而,许多重要的发现是通过以Eos为主要的 After antibody-dependent cell-mediated cytotoxicity (ADCC) has gained prominence in the mechanisms of tumor immunity and allograft rejection, Butterworth et al. First found that similar ADCC is also present in the anti-parasitic protective immune response. In the presence of human serum of Schistosoma mansoni, peripheral blood mononuclear cells kill schistosomorphs and further studies have shown that the effector cells are eosinophils (Eos). After that, extensive and in-depth studies on ADCC related to parasites were carried out. The targets involved a variety of nematodes and protozoa. Effector cells also included macrophages, neutrophils and NK cells. However, many of the important findings are through the predominant Eos