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意外反应增多是现代药物疗法的消极性方面之一。据《美国医生》的资料:10％住院病人及2.5％门诊病人在药疗中发现负性反应;2～7.9％病人系医源性疾病被迫住院。用药时发生负性反应的原因,发生机制及临床表现多种多样。药物的病理反应是药物与机体相互作用的结果,并取决于多种因素。取决于药物的因素中包括给药剂量,疗程持续时间,药物制剂纯度,杂合给药及不合理地合并用药的影响。取决于病人对药物反应的因素包括病人个体化的药物代谢动力学特征(吸收,在血液和组织中的分布,药物代谢特点,排泄),病人年龄,疾病阶段,机体药物代谢酶系统被诱导或
Increased unwanted reactions are one of the negative aspects of modern drug therapy. According to the data from the “American Doctor,” 10% of inpatients and 2.5% of outpatients found negative reactions in medical treatments; 2 to 7.9% of patients were hospitalized for iatrogenic diseases. The reasons for the negative reaction when taking medicine, the occurrence of a variety of mechanisms and clinical manifestations. The pathological response of a drug is the result of the drug’s interaction with the body and depends on many factors. Drug-dependent factors include the dose administered, the duration of the treatment, the purity of the pharmaceutical preparation, the effect of the combined administration, and the unjustified combination. Factors that depend on the patient’s response to the drug include the patient’s individual pharmacokinetic profile (absorption, distribution in the blood and tissues, characteristics of the drug metabolism, excretion), patient age, stage of the disease, systemic drug metabolism enzyme system is induced or