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骨硬化病或大理石骨病(Albers-schonberg disease)是一种罕见的疾病,其特点是骨骼密度增加,导致长骨骨髓腔发育障碍。这种病人的原因很久以来没有弄清楚。动物模型的发现才使病因学的研究有了新的进展。至1977年起,骨硬化病被确定为一种免疫遗传病。现在,法国科学研究中心(CNRS)的一个研究组提出,此病是由病毒引起的。他们发现,在出生时感染猫白血病逆转录病毒的猫患骨硬化病,合并胸腺退化性细胞免疫力降低。
Osteonecrosis or Albers-schonberg disease is a rare condition characterized by an increase in bone density leading to dysplastic development of the long bone marrow cavity. The reason for this patient has not been clear for a long time. The discovery of animal models makes etiological research has made new progress. Since 1977, osteopetrosis has been identified as an immunodeficiency disease. Now, a research team at the French Center for Scientific Research (CNRS) argues that the disease is caused by a virus. They found that cats born with feline leukemia retroviruses had osteosclerosis and decreased thymus degenerative cell immunity.