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解耦联蛋白是线粒体内膜上参与质子转运的蛋白质,具有调节机体产热、维持体温、调节能量平衡、调节ATP产生速度、控制活性氧产生、抗细胞凋亡等生理功能,参与许多疾病的病理生理学过程。文章就解耦联蛋白的基因、分布和调节、在周围组织和中枢神经系统中的作用及其与脑梗死的可能关系进行综述。
The uncoupling protein is a protein involved in the transport of protons in the mitochondrial inner membrane and has the functions of regulating body heat production, maintaining body temperature, regulating energy balance, regulating ATP production rate, controlling reactive oxygen species production, and anti-apoptosis, and participating in many diseases Pathophysiology process. The article reviews the gene, distribution and regulation of uncoupled proteins, their role in the surrounding tissues and the central nervous system, and their possible relationship to cerebral infarction.