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目的:进一步确定红核(RN)神经元能否感受外周血压的变化。方法:给大鼠静脉注射新福林使其血压升高,静脉注射酚妥拉明使其血压降低,作为血管压力感受性刺激。分别在保留和去除颈动脉窦主动脉弓压力感受器传入神经的条件下,观察外周血压变化对RN神经元单位放电频率的影响。结果,在保留颈动脉窦主动脉弓传入神经的条件下,当外周血压升高时,在记录到的74个RN单位中50.00%(37/74)呈增频反应,13.51%(10/74)呈减频反应,36.49%(27/74)无反应;当血压降低时,在记录到的47个RN单位中23.40%(11/47)呈增频反应,42.55%(20/47)呈减频反应,34.05%(16/47)无反应。如先去除颈动脉窦主动脉弓的传入神经,则当血压升高时,AN神经元中呈增频反应的明显减少,而当血压降低时,RN神经元中呈减频反应的明显减少。结论:RN神经元主要通过颈动脉窦主动脉弓压力感受器的传入神经感受外周血压的变化。
Objective: To further determine whether red nucleus (RN) neurons can feel the change of peripheral blood pressure. Methods: The rats were given intravenous injection of neoprene to raise their blood pressure, and phentolamine was given intravenously to lower their blood pressure as a vascular baroreceptor stimulus. The effects of changes of peripheral blood pressure on discharge frequency of RN neurons were observed under the conditions of preserving and removing the afferent nerves of carotid sinus aortic arch baroreceptor. As a result, 50.00% (37/74) of the 74 RN units recorded increased frequency of response when the peripheral blood pressure was elevated while preserving afferent nerves of the aortic arch of the carotid artery, and 13.51% ( (27/74) with no response; when the blood pressure decreased, 23.40% (11/47) of the 47 RN units recorded showed a frequency response, 42 .55% (20/47) showed a frequency response, 34.05% (16/47) no response. If the afferent nerves of the aortic arch of the carotid sinus are removed first, the frequency response of AN neurons is markedly reduced when the blood pressure is increased. When the blood pressure is decreased, the RN neurons are obviously reduced in frequency response. Conclusion: The changes of peripheral blood pressure in RN neurons mainly through afferent nerve of carotid sinus aortic arch baroreceptor.