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为了研究肺癌中p53基因的作用及突变类型与不同致癌物的可能关系,用PCR-SSCP核酸序列技术分析了原发非小细胞肺癌中p53基因的突变谱,结果发现128例中94例发生突变,其中86例为点突变,7例为缺失和插入突变,1例为拼接部位突变。点突变以G→T和T→G突变为主(63.9%),G→A和A→G占25.6%,这些结果提示p53基因突变与非小细胞肺癌发生有密切关系,并根据其突变特点分析了可能的环境致癌物。
In order to study the role of p53 gene and the possible relationship between mutation types and different carcinogens in lung cancer, the mutation spectrum of p53 gene in primary non-small cell lung cancer was analyzed by PCR-SSCP nucleic acid sequence technique. It was found that 94 out of 128 cases had mutations. Of these, 86 were point mutations, 7 were deletions and insertion mutations, and 1 was splice site mutations. The point mutations were dominated by G→T and T→G mutations (63.9%), and G→A and A→G accounted for 25.6%. These results suggest that the p53 gene mutation is closely related to the occurrence of non-small cell lung cancer, and Based on its mutation characteristics, possible environmental carcinogens were analyzed.