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45例细菌感染患者随机分为两组:常规用药组(AMK 400mg/d)和个体化用药组。结果表明常规用药组AMK血浓度大都低于治疗浓度,疗效仅29%;而个体化用药组血清AMK浓度基本上都在理想治疗浓度范围,疗效达85.7%。两组间耳、肾毒性发生率无明显区别,为AMK的合理用药提供了一个较实用可行的方案。
Forty-five patients with bacterial infection were randomly divided into two groups: conventional drug group (AMK 400 mg / d) and individualized drug group. The results showed that most of the AMK blood concentration in the conventional treatment group was lower than the therapeutic concentration, with a curative effect of only 29%. However, the serum AMK concentration in the individualized treatment group was basically within the ideal therapeutic concentration range, with a therapeutic effect of 85.7%. There was no significant difference between the two groups in the incidence of ototoxicity and nephrotoxicity, which provided a more practical and feasible solution for the rational use of AMK.