皮肤纤维瘤系指一组有各种不同组织象的皮肤反应的通称。病变局限性,无包膜,主要由成纤维细胞组成(皮肤纤维瘤),或主要由泡沫样组织细胞及新生血管组成(硬化性血管瘤),乃至主要由组织细胞所组成(组织细胞瘤)。本病是一种常见的良性肿瘤,具有特殊的临床表现易于诊断。当出现不典型损害时,则与其他疾病相似。作者报导一例不典型皮肤纤维瘤,讨论临床鉴别诊断及复习有关资料。患者男性,52岁。右下肢胫前缓慢生长角化过 Dermatofibroma is a generic term for a group of skin reactions that have a variety of different tissue patterns. Localized lesions, no capsule, mainly composed of fibroblasts (dermatofibromas), or mainly composed of foam-like tissue cells and neovascularization (sclerosing hemangiomas), or even composed of tissue cells (tissue cell tumor) . The disease is a common benign tumor with a special clinical manifestation that is easy to diagnose. When atypical damage occurs, it is similar to other diseases. The authors reported a case of atypical dermatofibromas and discussed clinical differential diagnosis and review of relevant data. The patient is male, 52 years old. Slowly growing keratinized before the right lower limb