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肝细胞癌(hepatocellular carcinoma,HCC)是我国及亚非地区较常见的恶性肿瘤。目前对导致肝癌发生的具体病因还不是很清楚,致癌物的大量接触是肝癌发生的一个重要原因,但是在同样的条件下有的人患病,有的人不患病,这提示遗传易感性在其中起着重要的作用。分子流行病学研究表明乙型肝炎病毒(hepatitis B virus,HBV)感染是高发地区肝细胞癌发生的基本病因。HBV长期感染,经常发生病毒基因整合到肝细胞的DNA中。HBV 4个基因中的X基因被认为是潜在的
Hepatocellular carcinoma (HCC) is a common malignant tumor in China and Asia and Africa. At present, the specific etiopathogenisis of hepatocarcinogenesis is not yet clear. Massive carcinogen contact is an important cause of hepatocellular carcinoma. However, under the same conditions, some people are sick and some are not affected. This suggests that genetic susceptibility In which plays an important role. Molecular epidemiological studies have shown that hepatitis B virus (HBV) infection is the basic cause of hepatocellular carcinoma in high incidence areas. Long-term HBV infection, often occurs in the integration of viral genes into the DNA of hepatocytes. The X gene in the 4 HBV genes is considered to be potential