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目的 研究一氧化氮 (NO)在类风湿性关节炎 (RA)及骨关节炎 (OA)病变中的作用。方法 采用亚硝酸盐间接法测定了 40例RA、2 0例OA患者血清及滑液NO的含量变化 ,并与年龄相匹配的健康人相比较。结果 RA患者血清及滑液NO的浓度呈正相关 (r =0 417,P <0 0 5 )。RA和OA患者血清NO浓度均低于滑液中的 ,但显著高于正常对照组血清NO浓度 ;RA患者滑液NO浓度高于血清中 ,且明显高于OA组滑液NO浓度。结论 NO在RA和OA患者骨关节中可能主要由滑膜产生 ;NO可能参与了类风湿性关节炎病变过程 ,且在其中起一定损害作用
Objective To study the role of nitric oxide (NO) in the pathogenesis of rheumatoid arthritis (RA) and osteoarthritis (OA). Methods The contents of NO in serum and synovial fluid in 40 patients with RA and 20 OA patients were measured by nitrite indirect method and compared with age-matched healthy people. Results The concentration of NO in serum and synovial fluid of RA patients was positively correlated (r = 0 417, P <0 05). Serum NO concentrations in RA and OA patients were lower than those in synovial fluid, but significantly higher than those in normal control group. The synovial NO concentration in RA patients was significantly higher than that in serum and significantly higher than that in OA. CONCLUSIONS: NO may be mainly produced by synovium in the joints of RA and OA patients. NO may be involved in the pathological process of rheumatoid arthritis and play a role in lesion