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目的观察探究疏肝益肾汤加减对子宫内膜癌术后化疗的增效减毒作用。方法 100例接受手术治疗的子宫内膜癌患者作为研究对象,采用随机数字表法分为对照组和观察组,各50例。对照组施以环磷酰胺(CTX)、顺铂(DDP)、阿霉素(ADM)、紫杉醇(PTX)、足叶乙甙(VP16)等常规联合化疗,观察组在此基础上服用疏肝益肾汤辅助治疗。对两组患者实施随访,对两组患者治疗1年后的生活质量评分、3年后的存活率及复发转移率、6个月后的外周血白细胞计数进行对比。结果治疗1年后,观察组患者的生活质量评分为(87.12±8.23)分,高于对照组的(71.06±4.01)分,差异具有统计学意义(P<0.05)。治疗3年后,观察组患者的存活率为86.0%、复发转移率为10.0%,均优于对照组的68.0%、28.0%,差异均具有统计学意义(P<0.05)。治疗6个月后,观察组患者的外周血白细胞计数为(3.91±0.58)×10~9/L,优于对照组的(2.83±0.12)×10~9/L,差异具有统计学意义(P<0.05)。结论子宫内膜癌患者术后化疗期服用疏肝益肾汤加减治疗,可以有效提高患者的免疫力,增进治疗效果,对于改善患者生活质量、提高患者生存率、降低复发转移率具有突出效果,值得临床推广。
Objective To observe the effect of Shugan Yishen Decoction on the efficiency and attenuation of postoperative chemotherapy of endometrial carcinoma. Methods 100 cases of endometrial cancer patients undergoing surgery were divided into control group and observation group using random number table method, 50 cases each. The control group was given conventional chemotherapy such as cyclophosphamide (CTX), cisplatin (DDP), doxorubicin (ADM), paclitaxel (PTX) and etoposide (VP16) Kidney soup adjuvant therapy. The two groups were followed up, the quality of life scores after 1 year, the survival rate after 3 years, the recurrence and metastasis rate and the peripheral blood leukocyte count after 6 months were compared. Results After 1 year of treatment, the quality of life of the observation group was (87.12 ± 8.23) points higher than that of the control group (71.06 ± 4.01), the difference was statistically significant (P <0.05). After 3 years of treatment, the survival rate of the observation group was 86.0%, and the recurrence and metastasis rate was 10.0%, both of which were better than 68.0% and 28.0% of the control group, respectively. The difference was statistically significant (P <0.05). After 6 months’ treatment, the peripheral blood leukocyte count in observation group was (3.91 ± 0.58) × 10 ~ 9 / L, which was significantly higher than that in control group (2.83 ± 0.12) × 10 ~ 9 / L P <0.05). Conclusion The treatment of endometrial cancer patients with chemotherapy after Shuguyishen Decoction can effectively improve the patient’s immune system and improve the treatment effect for improving the patient’s quality of life and improve patient survival rate and reduce the recurrence and metastasis rate has a prominent effect, Worth clinical promotion.