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虽然基底细胞癌(BCC)是一种典型的缓慢生长的肿瘤,可复发,很少转移。但生物学上更具侵袭性的病例近来有所增多。变异型癌(metatypical carcinoma,MTC)可能较BCC具有更高的生物学侵袭性。但仅有很少作者对该病的特征进行研究。为此,作者采用石蜡切片的免疫组化方法,观察32例原发BCC、10例复发BCC和10例MTC的增殖细胞核抗原(PCNA)、平滑肌收缩蛋白和细胞角蛋白的表达,以期提供更多的有关诊断及预后的信息。 结果表明:①未受累表皮,PCNA抗体染色阳性的细胞核通常局限于少数基底细胞。在原发BCC,PCNA阳性核通常呈弥散分布(24例),但有时亦局限于肿瘤小叶的外周区(8例)。复发BCC的PCNA阳性核分布类似于原发BCC,70％呈弥散分布,30％呈局限分布。MTC均为弥散性分布。但在复发BCC和
Although basal cell carcinoma (BCC) is a typical slow-growing tumor, it can relapse and rarely metastasize. But biologically more aggressive cases have recently increased. Metatypical carcinoma (MTC) may be more biologically invasive than BCC. However, only a few authors have studied the characteristics of the disease. To this end, the authors used paraffin section immunohistochemistry to observe the expression of proliferating cell nuclear antigen (PCNA), smooth muscle contractile protein, and cytokeratin in 32 cases of primary BCC, 10 cases of recurrent BCC, and 10 cases of MTC in order to provide more Information about diagnosis and prognosis. The results showed that: (1) In the uninvolved epidermis, nuclei that stained positive for PCNA antibodies were usually limited to a few basal cells. In primary BCC, PCNA-positive nuclei are usually diffusely distributed (24 cases), but are also sometimes confined to the peripheral regions of the tumor lobules (8 cases). The PCNA-positive nuclear distribution of recurrent BCC was similar to that of primary BCC, 70% was diffusely distributed, and 30% was localized. MTC is diffusely distributed. But in relapsed BCC and