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目的:评价尼美舒利和布洛芬治疗儿童发热的疗效和安全性。方法:计算机检索Pubmed,Cochrane图书馆、CNKI,CBM,维普、万方6个数据库,采用Cochrane系统评价方法对纳入的随机对照试验(RCTs)进行方法学质量评价,并用Revman 5.0.0软件进行Meta分析。结果:共纳入24项RCTs,共计3 773例患者。Meta分析结果显示,尼美舒利与布洛芬相比,治疗1 h(RR=1.34,95%CI:[1.18,1.52],P<0.000 01)和6 h(RR=1.26,95%CI:[1.15,1.37],P<0.000 01)后的疗效差异均有统计学意义,安全性方面二者在恶心、呕吐(RR=0.23,95%CI:[0.13,0.40],P<0.000 01)以及嗜睡(RR=6.43,95%CI:[1.19,34.65],P=0.03)发生率上差异有统计学意义。结论:尼美舒利治疗儿童发热疗效优于布洛芬,安全性还有待进一步研究。
PURPOSE: To evaluate the efficacy and safety of nimesulide and ibuprofen in the treatment of fever in children. Methods: The databases of Pubmed, Cochrane Library, CNKI, CBM, Vip and Wanfang were searched by computer. The methodological quality of randomized controlled trials (RCTs) included in the Cochrane systematic review was evaluated. The Revman 5.0.0 software was used for Meta analysis. Results: A total of 24 RCTs were included, totaling 3,773 patients. Meta-analysis revealed that nimesulide was associated with ibuprofen at 1 h (RR = 1.34, 95% CI: 1.18, 1.52; P <0.000 01) and 6 h (RR = 1.26, 95% CI : [1.15,1.37], P <0.000 01). There were significant differences in the safety between the two groups in nausea and vomiting (RR = 0.23, 95% CI: [0.13, 0.40], P <0.000 01 ) And lethargy (RR = 6.43, 95% CI: [1.19,34.65], P = 0.03), the difference was statistically significant. Conclusion: Nimesulide treatment of children with fever is superior to ibuprofen, safety remains to be further studied.