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[目的]用Sprague Dawley(SD)大鼠为试材,测定95%咪唑烟酸原药对动物致畸方面的影响。[方法]通过大鼠的致畸试验,来测定95%咪唑烟酸原药对动物致畸的影响。[结果]大鼠经口灌胃给予95%咪唑烟酸原药200、400、800 mg/kg三个剂量组时,95%咪唑烟酸原药对孕鼠及胎鼠的最大无作用剂量为800 mg/kg。[结论]根椐试验的结果并综合其他有关的试验数据,95%咪唑烟酸原药对孕鼠及胎鼠没有明显毒性作用。
[Objective] The purpose of this study was to determine the effect of 95% imidazole nicotinic acid on teratogenicity in Sprague Dawley (SD) rats. [Method] Teratogenicity test in rats was used to determine the effect of 95% imidazole nicotinic acid on teratogenicity in animals. [Result] When the rats were orally administered 95% imidacloprid of original dose of 200, 400 and 800 mg / kg, the maximum non-acting dose of 95% imidazole nicotinic acid for pregnant rats and fetus was 800 mg / kg. [Conclusion] According to the results of root 椐 test and other relevant experimental data, 95% imidazole niacin has no obvious toxic effect on pregnant rats and fetus.