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目的探讨肿瘤坏死因子(tumor necrosis factor,TNF)-α基因启动子区238位点单核苷酸多态性(single nucleotide polymorphism,SNP)与脑梗死(cerebral infarction,CI)易感性的关联情况。方法通过中国生物医学文献数据库、中国期刊网全文数据库、万方、维普,Pub Med、Cochrane图书馆、Ovid SP、Wiley Online图书馆、EBSCO、Elsevier Science Direct、Springer Link数据库检索TNF-α-238位点SNP与CI相关的病例-对照研究,利用Rev Man 5.3和Stata 12.0软件对各研究数据进行综合统计分析。结果共纳入10篇文献,包括4 042例CI患者和3 655例对照。CI组与对照组相比,GG基因型频率(OR=0.72,95%CI:0.55~0.96,P=0.020)、G等位基因频率(OR=0.69,95%CI:0.50~0.95,P=0.020)、A等位基因频率(OR=1.46,95%CI:1.06~2.01,P=0.020)差异有统计学意义,提示携有GG基因型和G等位基因者罹患CI的风险降低、携有A等位基因者罹患CI的风险增高。结论TNF-α基因启动子区238位点SNP与CI易感性之间有关联性。
Objective To investigate the association between single nucleotide polymorphism (SNP) at the 238 locus in the promoter region of tumor necrosis factor (TNF) -α gene and the susceptibility to cerebral infarction (CI). Methods The TNF-α-238 gene was searched by the Chinese Biomedical Literature Database, Chinese Journal Net Full-text Database, Wanfang, VIP, Pub Med, Cochrane Library, Ovid SP, Wiley Online Library, EBSCO, Elsevier Science Direct and Springer Link Point-by-point SNP-related case-control study, the use of Rev Man 5.3 and Stata 12.0 software to conduct a comprehensive statistical analysis of the data. Results A total of 10 articles were included, including 4 042 CI patients and 3 655 controls. The frequency of G allele (OR = 0.72, 95% CI: 0.55-0.96, P = 0.020) and G allele frequency (OR = 0.69, 95% CI: 0.50-0.95, P = 0.020). There was significant difference in the frequency of allele A (OR = 1.46, 95% CI: 1.06-2.01, P = 0.020), suggesting a lower risk of CI with GG genotype and G allele Patients with the A allele have a higher risk of developing CI. Conclusion There is a correlation between SNP at 238 locus and susceptibility to CI in TNF-α gene promoter region.