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目的通过对接受雷帕霉素洗脱支架(sirolimus-eluting stent,SES)治疗的冠心病患者冠状动脉造影随访,观察其临床实际应用的效果。方法339例患者接受治疗,所有患者均接受了临床随访,165例患者于置入术后6~12个月行冠状动脉造影复查。结果冠状动脉造影随访时,支架近端边缘晚期管腔丢失显著高于支架内及支架远端边缘(0.17 mmvs0.08 mmvs0.09 mm),再狭窄率为9.7%,再血管化率4.84%,再狭窄以局限性狭窄为主。在339例患者中,有4例患者于支架置入后5天~4个月发生猝死。猝死发生率为1.18%。1例于支架置入后14天发生支架内亚急性血栓形成,发生率0.50%。晚期血栓形成1例(术后12个月),主要心血管不良事件为1.70%。结论对复杂的冠状动脉病变SES有较好的疗效,能显著降低支架后再狭窄,减少靶血管的再血管化率。
Objective To follow-up coronary angiography in coronary heart disease patients treated with sirolimus-eluting stent (SES) and observe its clinical application. Methods 339 patients were treated, all patients were followed up, and 165 patients underwent coronary angiography 6 to 12 months postoperatively. Results During the coronary angiography follow-up, the late luminal loss at the proximal margin of the stent was significantly higher than that of the stent and the distal edge of the stent (0.17 mm vs 0.08 mm vs 0.09 mm). The restenosis rate was 9.7% and the rate of revascularization was 4.84% Restenosis to the main limitations of stenosis. Of the 339 patients, 4 died suddenly 5 days to 4 months after stenting. The incidence of sudden death was 1.18%. One case had intracranial subacute thrombosis occurring 14 days after stenting, with an incidence of 0.50%. One patient had advanced thrombosis (12 months postoperatively), with a major adverse cardiovascular event of 1.70%. Conclusion SES has a good curative effect on complex coronary artery lesion and can significantly reduce the restenosis after stent and reduce the rate of revascularization of target vessel.