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肺癌的早期发现和诊断是治疗的关键所在。外周血肿瘤标志物的检测具有无创伤、可重复、费用低等优点是肺癌诊断和随访的理想手段。微卫星DNA(microsatellite,MS)是指以少数几个核苷酸为单位多次串联重复的DNA序列。微卫星异常主要表现为微卫星不稳定性(microsatellite instability,MSI)和杂合性丢失(loss of heterozygosity,LOH)。微小RNA(micro RNA,mi RNA)是一种非编码蛋白的RNA,参与转录后水平基因的表达调控。近年来,越来越多的研究提示外周血微卫星改变和mi RNA标志物的表达也表现为显著的肿瘤相关性、组织特异性和表达稳定性。本文就外周血微卫星改变和微小RNA的检测与肺癌相关性的研究新进展作一综述。
Early detection and diagnosis of lung cancer is the key to treatment. Detection of peripheral blood tumor markers with non-invasive, repeatable, low cost advantages such as lung cancer diagnosis and follow-up of the ideal means. Microsatellite (MS) refers to a DNA sequence that is repeated in tandem over a few nucleotides. Microsatellite anomalies mainly show microsatellite instability (MSI) and loss of heterozygosity (LOH). Micro RNA (miRNA) is a kind of non-coding RNA that participates in the regulation of gene expression at the post-transcriptional level. In recent years, more and more researches suggest that the changes of microsatellite DNA in peripheral blood and the expression of miRNA markers also show significant tumor-related, tissue-specific and stable expression. This review summarizes recent progress in the study of the relationship between microsatellite changes in peripheral blood and the detection of microRNAs and lung cancer.