论文部分内容阅读
目的:探讨凋亡抑制蛋白surv iv in在膀胱移行细胞癌中的表达及其与bcl-2蛋白表达的相关性。方法:应用免疫组化方法,检测43例膀胱移行细胞癌标本中surv iv in、bcl-2蛋白的表达,15例正常膀胱黏膜移行上皮进行对照研究。结果:43例膀胱移行细胞癌组织中,surv iv in蛋白阳性表达率为67.4%,而正常膀胱黏膜组织中未见surv iv in蛋白阳性表达。surv iv in蛋白表达与膀胱移行细胞癌临床分期、病理分级相关。surv iv in蛋白与bcl-2蛋白表达负相关(P<0.01)。结论:surv iv in基因可通过抑制膀胱移行癌细胞凋亡,对膀胱移行细胞癌的发生发展起作用。
Objective: To investigate the expression of surviv in apoptosis in bladder transitional cell carcinoma and its relationship with bcl-2 protein expression. Methods: The expressions of survivin and bcl-2 protein in 43 specimens of bladder transitional cell carcinoma were detected by immunohistochemistry. Fifteen cases of normal bladder mucosa transitional epithelium were studied. Results: The positive expression rate of survivin in 43 cases of transitional cell carcinoma of urinary bladder was 67.4%, while no expression of survivin was found in normal bladder mucosa. The expression of survivin was correlated with the clinical stage and pathological grade of bladder transitional cell carcinoma. Survivin protein was negatively correlated with bcl-2 protein expression (P <0.01). Conclusion: Survivin gene may play a role in the occurrence and development of bladder transitional cell carcinoma by inhibiting the apoptosis of bladder transitional cell carcinoma.